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ANTIOXIDANT CAPACITY AND QUANTIFICATION ANALYSIS OF CHEMICAL CONSTITUENTS ISOLATED FROM TETRASTIGMA HEMSLEYANUM LEAVES

期刊: ACTA POLONIAE PHARMACEUTICA, 2021; 78 (3)

Tetrastigma hemsleyanum is an edible and medicinal plant in China. There are little researches on its leaves as the root is the conventionally used pa......

SYNTHESIS AND EVALUATION OF NOVEL BONE-TARGETING IBUPROFEN PRODRUG BASED ON DENDRITIC ASPARTIC ACID

期刊: ACTA POLONIAE PHARMACEUTICA, 2021; 78 (3)

Bone diseases, such as osteoarthritis, osteomyelitis, are notoriously difficult diseases to treat due to the comparatively low blood flows in bone tis......

EFFECTS OF DEXMEDETOMIDINE ON ACTIVATING INTESTINAL GLIAL CELLS

期刊: ACTA POLONIAE PHARMACEUTICA, 2021; 78 (3)

In this study, glial cell-derived neurotrophic factor GDNF was used as an evaluation index to explore the effect of dexmedetomidine, a commonly used c......

METABOLOMICS ANALYSIS ON DIFFERENT PARTS OF ACANTHOPANAX SENTICOSUS BASED ON UPLC-Q-TOF-MS

期刊: ACTA POLONIAE PHARMACEUTICA, 2021; 78 (2)

Acanthopanax senticosus roots, rhizomes, or stems are the main site of ciwujia. Due to the limited resources of the roots, the leaves and pulp are som......

UNDERSTANDING THE MOLECULAR LINK BETWEEN MIRNA 92A AND CXCR2 IN REGULATING CANCER STEM CELLS IN THE PROGRESSION OF COLON CANCER

期刊: ACTA POLONIAE PHARMACEUTICA, 2021; 78 (1)

Colon cancer is one of the leading cancer types that positioned the 3rd rank in the global level. The role of CXCR2 and CD133 is reported in many diff......

DRUG RELEASE OF NANO-HYDROXYAPATITE BIOLOGICAL SUBSTITUTE LOADED WITH ISONIAZID AND RIFAMPIN IN VITRO AND ANIMAL MODELS OF SPINAL TUBERCULOSIS

期刊: ACTA POLONIAE PHARMACEUTICA, 2021; 78 (2)

Spinal tuberculosis drug efficacy studies have shown that a drug's clinical efficacy mainly depends on its concentration in the target tissue. To impr......

6-GINGEROL PROMOTES G2/M PHASE CELL CYCLE ARREST AND APOPTOSIS IN HEPATOCELLULAR CARCINOMA

期刊: ACTA POLONIAE PHARMACEUTICA, 2021; 78 (1)

6-Gingerol (6-G), an active biological natural polyphenolic compound extracted from ginger (Zingiber officinale) has been reported to exhibit promisin......

THE PRELIMINARY STUDY OF HUANGQI SANYAN DECOCTION BONE-TARGETED LIPOSOME AND IN VITRO EVALUATION OF BONE TARGETING

期刊: ACTA POLONIAE PHARMACEUTICA, 2021; 78 (3)

In this study, we explored and optimized the preparation process of bone-targeting liposomes from the effective components of Huangqi Sanyan decoction......

PROTECTIVE EFFECTS OF ISOLIQUIRITIN ON BEAS-2B CELLS AGAINST LPS-INDUCED OXIDATIVE STRESS AND INFLAMMATION INVOLVING ACTIVATION OF NRF2

期刊: ACTA POLONIAE PHARMACEUTICA, 2021; 78 (3)

Inflammatory respiratory diseases such as chronic obstructive pulmonary disease (COPD) threaten people's health worldwide. To discover novel drugs tar......

SKULLCAPFLAVONE II INHIBITS PROLIFERATION, MIGRATION, INVASION AND PROMOTES APOPTOSIS OF BREAST CANCER CELLS BY ATTENUATION OF PI3K/AKT/MTOR PATHWAY

期刊: ACTA POLONIAE PHARMACEUTICA, 2021; 78 (3)

Breast cancer is the leading cause of mortality in women across the globe. The study therefore designed to evaluate the effect of Skullcapflavone II (......

NOVEL EVALUATIONS OF PROTOCATECHUIC ACID TO TARGET IL-17A FOR PSORIASIS PROTECTION IN MICE

期刊: ACTA POLONIAE PHARMACEUTICA, 2021; 78 (1)

Psoriasis is an erythrogenic skin condition identified by multi-layered scales in addition to the thick epidermis (top layer of the skin). The functio......

PIPERINE MODULATES NLRP3 / TLR4 / NF-kappa B SIGNALLING PROCESSES OF ANGIOGENESIS AND NEUROGENESIS IN RATS FOLLOWING ISCHEMIC STROKE

期刊: ACTA POLONIAE PHARMACEUTICA, 2021; 78 (2)

Early studies have shown neurotrophic and neuroprotective functions and have grown considerably in the treatment of brain aging-related disorders corr......

CBX7 AND HOXC10 PROMOTE GASTRIC CANCER CELL PROLIFERATION AND METASTASIS THROUGH NF-kappa B ACTIVATION

期刊: ACTA POLONIAE PHARMACEUTICA, 2021; 78 (1)

Identification of prognostic biomarkers and molecular mechanisms involved in the carcinogenesis of gastric cancer will expedite the innovation of new ......

IN VITRO BIOACCESSIBILITY ANALYSIS AND SAFETY ASSESSMENT OF ESSENTIAL AND TOXIC TRACE ELEMENTS FROM TEN HERBAL MEDICINES WIDELY USED IN CHINA

期刊: ACTA POLONIAE PHARMACEUTICA, 2021; 78 (1)

Research of trace elements (TEs) in herbal medicines is growing, owing to their nutritional and medicinal properties, as well as their toxic effects. ......

BIFENDATE INDIRECTLY INHIBITS ALANINE TRANSAMINASE RELEASE WITHOUT DIRECT INTERACTION IN VITRO AND IN VIVO

期刊: ACTA POLONIAE PHARMACEUTICA, 2020; 77 (4)

Bifendate (DDB) is an approved hepatoprotective drug for decreasing serum transaminases in patients with chronic hepatitis in China. However, in some ......

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