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Long non-coding RNA MIR200CHG promotes breast cancer proliferation, invasion, and drug resistance by interacting with and stabilizing YB-1

期刊: NPJ BREAST CANCER, 2021; 7 (1)

Long non-coding RNAs (lncRNA) have been identified as key regulators of tumorigenesis and development. We aim to explore the biological functions and ......

How can artificial intelligence models assist PD-L1 expression scoring in breast cancer: results of multi-institutional ring studies

期刊: NPJ BREAST CANCER, 2021; 7 (1)

Programmed death ligand-1 (PD-L1) expression is a key biomarker to screen patients for PD-1/PD-L1-targeted immunotherapy. However, a subjective assess......

Systemic immune reaction in axillary lymph nodes adds to tumor-infiltrating lymphocytes in triple-negative breast cancer prognostication

期刊: NPJ BREAST CANCER, 2021; 7 (1)

The level of stromal tumor-infiltrating lymphocytes (sTILs) in triple-negative (TNBC) and HER2-positive breast cancers convey prognostic information. ......

RIPK1 is a negative mediator in Aquaporin 1-driven triple-negative breast carcinoma progression and metastasis

期刊: NPJ BREAST CANCER, 2021; 7 (1)

The triple-negative breast carcinoma (TNBC) is the most aggressive subtype of breast cancer. In TNBC, Aquaporin 1 (AQP1), a water-transporting transme......

Impact of dose-dense neoadjuvant chemotherapy on pathologic response and survival for HER2-positive breast cancer patients who receive trastuzumab

期刊: NPJ BREAST CANCER, 2021; 7 (1)

To compare outcomes in patients with human epidermal growth factor receptor-2 (HER2)-positive breast cancer who received either dose-dense neoadjuvant......

Circulating cell-free DNA-based methylation patterns for breast cancer diagnosis

期刊: NPJ BREAST CANCER, 2021; 7 (1)

Mammography is used to detect breast cancer (BC), but its sensitivity is limited, especially for dense breasts. Circulating cell-free DNA (cfDNA) meth......

Collagen fiber orientation disorder from H&E images is prognostic for early stage breast cancer: clinical trial validation

期刊: NPJ BREAST CANCER, 2021; 7 (1)

Collagen fiber organization has been found to be implicated in breast cancer prognosis. In this study, we evaluated whether computerized features of C......

Signaling of MK2 sustains robust AP1 activity for triple negative breast cancer tumorigenesis through direct phosphorylation of JAB1

期刊: NPJ BREAST CANCER, 2021; 7 (1)

Triple negative breast cancer (TNBC) cells are generally more invasive than estrogen receptor-positive (ER + ) breast cancer cells. Consistent with th......

Establishment and characterization of immortalized human breast cancer cell lines from breast cancer patient-derived xenografts (PDX)

期刊: NPJ BREAST CANCER, 2021; 7 (1)

The application of patient-derived xenografts (PDX) in drug screening and testing is a costly and time-consuming endeavor. While cell lines permit ext......

Genetic interactions among Brca1, Brca2, Palb2, and Trp53 in mammary tumor development

期刊: NPJ BREAST CANCER, 2021; 7 (1)

Inherited mutations in BRCA1, BRCA2, and PALB2 cause a high risk of breast cancer. Here, we conducted parallel conditional knockout (CKO) of Brca1, Pa......

Automated and rapid detection of cancer in suspicious axillary lymph nodes in patients with breast cancer

期刊: NPJ BREAST CANCER, 2021; 7 (1)

Preoperative staging of suspicious axillary lymph nodes (ALNs) allows patients to be triaged to ALN dissection or to sentinel lymph node biopsy (SLNB)......

Circulating tRNA-derived small RNAs (tsRNAs) signature for the diagnosis and prognosis of breast cancer

期刊: NPJ BREAST CANCER, 2021; 7 (1)

Liquid biopsy is noninvasive and convenient to detect cancer-derived materials in blood or other body fluids. The aim of this study was to identify tR......

Association between the nucleosome footprint of plasma DNA and neoadjuvant chemotherapy response for breast cancer

期刊: NPJ BREAST CANCER, 2021; 7 (1)

Gene expression signatures have been used to predict the outcome of chemotherapy for breast cancer. The nucleosome footprint of cell-free DNA (cfDNA) ......

Risk of hematologic malignancies after breast ductal carcinoma in situ treatment with ionizing radiation

期刊: NPJ BREAST CANCER, 2021; 7 (1)

The increased incidence of secondary hematologic malignancies (SHM) is a well-known, potentially fatal, complication after cancer treatment. It is unk......

Incorporation of biologic factors for the staging of de novo stage IV breast cancer

期刊: NPJ BREAST CANCER, 2020; 6 (1)

This study aimed to investigate the prognostic value of biological factors, including histological grade, estrogen receptor (ER), progesterone recepto......

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