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Evaluation of common genetic variants in vitamin E-related pathway genes and colorectal cancer susceptibility

期刊: ARCHIVES OF TOXICOLOGY, 2021; 95 (7)

Vitamin E is effective for preventing the risk of cancer. However, few studies have elucidated the mechanism of vitamin E in cancer occurrence. Herein......

Progress in protecting vestibular hair cells

期刊: ARCHIVES OF TOXICOLOGY, 2021; 95 (8)

Vestibular hair cells are mechanosensory receptors that are capable of detecting changes in head position and thereby allow animals to maintain their ......

Genetic variations in the CTLA-4 immune checkpoint pathway are associated with colon cancer risk, prognosis, and immune infiltration via regulation of IQCB1 expression

期刊: ARCHIVES OF TOXICOLOGY, 2021; 95 (6)

The programmed cell death-1 (PD-1)/cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) immune checkpoint pathways serve as targets of immunotherapy f......

Assessment of long-term functional maintenance of primary human hepatocytes to predict drug-induced hepatoxicity in vitro

期刊: ARCHIVES OF TOXICOLOGY, 2021; 95 (7)

Hepatocytes are the main cell components of the liver and perform metabolic, detoxification, and endocrine functions. Functional hepatocytes are of gr......

Ensemble machine learning to evaluate the in vivo acute oral toxicity and in vitro human acetylcholinesterase inhibitory activity of organophosphates

期刊: ARCHIVES OF TOXICOLOGY, 2021; 95 (7)

Organophosphates (OPs) are hazardous chemicals widely used in industry and agriculture. Distribution of their residues in nature causes serious risks ......

Aristolochic acid IVa forms DNA adducts in vitro but is non-genotoxic in vivo

期刊: ARCHIVES OF TOXICOLOGY, 2021; 95 (8)

Aristolochic acids (AAs) are a family of natural compounds with AA I and AA II being known carcinogens, whose bioactivation causes DNA adducts formati......

Selection of safe artemisinin derivatives using a machine learning-based cardiotoxicity platform and in vitro and in vivo validation

期刊: ARCHIVES OF TOXICOLOGY, 2021; 95 (7)

The majority of drug candidates fails the approval phase due to unwanted toxicities and side effects. Establishment of an effective toxicity predictio......

Acute exposure to microcystin-LR induces hepatopancreas toxicity in the Chinese mitten crab (Eriocheir sinensis)

期刊: ARCHIVES OF TOXICOLOGY, 2021; 95 (7)

The Chinese mitten crab is an important economic species in the Chinese aquaculture industry due to its rich nutritional value and distinct flavor. Th......

LncRNA H19 modulated by miR-146b-3p/miR-1539-mediated allelic regulation in transarterial chemoembolization of hepatocellular carcinoma

期刊: ARCHIVES OF TOXICOLOGY, 2021; 95 (9)

Transarterial chemoembolization (TACE) is an effective treatment for unresectable hepatocellular carcinoma (HCC) patients. Although overall survival (......

A 6-month inhalation toxicology study in Apoe(-/-) mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract

期刊: ARCHIVES OF TOXICOLOGY, 2021; 95 (5)

Cigarette smoking is the major cause of chronic obstructive pulmonary disease. Considerable attention has been paid to the reduced harm potential of n......

Metabolism-mediated cytotoxicity and genotoxicity of pyrrolizidine alkaloids

期刊: ARCHIVES OF TOXICOLOGY, 2021; 95 (6)

Pyrrolizidine alkaloids (PAs) and PA N-oxides are common phytotoxins produced by over 6000 plant species. Humans are frequently exposed to PAs via ing......

Ochratoxin A induces nephrotoxicity in vitro and in vivo via pyroptosis

期刊: ARCHIVES OF TOXICOLOGY, ; ()

Ochratoxin A (OTA), a prevalent nephrotoxic mycotoxin contaminant in food and feedstuff, has been reported to induce renal injury. To disclose the nep......

Carbon monoxide-triggered health effects: the important role of the inflammasome and its possible crosstalk with autophagy and exosomes

期刊: ARCHIVES OF TOXICOLOGY, ; ()

Carbon monoxide (CO) has long been known as a "silent killer" because of its ability to bind hemoglobin (Hb), leading to reduced oxygen carrying capac......

N6-methyladenosine reader YTHDC2 and eraser FTO may determine hepatocellular carcinoma prognoses after transarterial chemoembolization

期刊: ARCHIVES OF TOXICOLOGY, ; ()

Transarterial chemoembolization (TACE) has significantly improved overall survival (OS) of unresectable hepatocellular carcinoma (HCC) patients. Unfor......

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