Selection of safe artemisinin derivatives using a machine learning-based cardiotoxicity platform and in vitro and in vivo validation

Kadioglu, O; Klauck, SM; Fleischer, E; Shan, LT; Efferth, T

Efferth, T (corresponding author), Johannes Gutenberg Univ Mainz, Inst Pharmaceut & Biomed Sci, Dept Pharmaceut Biol, Staudinger Weg 5, D-55128 Mainz, Germany.

ARCHIVES OF TOXICOLOGY, 2021; 95 (7): 2485

Abstract

The majority of drug candidates fails the approval phase due to unwanted toxicities and side effects. Establishment of an effective toxicity predictio......

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