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Adverse event profiles of epidermal growth factor receptor-tyrosine kinase inhibitors in cancer patients: A systematic review and meta-analysis

期刊: CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2021; 14 (3)

The efficacy of agents targeting epidermal growth factor receptor (EGFR) in patients with various cancers was well elucidated. However, the safety pro......

Effect of selenium on thyroid autoimmunity and regulatory T cells in patients with Hashimoto's thyroiditis: A prospective randomized-controlled trial

期刊: CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2021; 14 (4)

Selenium (Se) is an essential trace element in human. Recent studies of Se supplementation on the effect of Hashimoto's thyroiditis (HT) have been rep......

Metabolomics analysis of the serum from children with urolithiasis using UPLC-MS

期刊: CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2021; 14 (4)

Pediatric urolithiasis is a common urologic disease with high morbidity and recurrence rates. Recent studies have shown that metabolic dysfunction pla......

Effects on the Ocular Surface from Reading on Different Smartphone Screens: A Prospective Randomized Controlled Study

期刊: CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2021; 14 (3)

The purpose of this study was to investigate the influence of smartphone reading on the ocular surface and to compare the various effects of different......

Asia-inclusive global development of pevonedistat: Clinical pharmacology and translational research enabling a phase 3 multiregional clinical trial

期刊: CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2021; 14 (3)

The investigational NEDD8-activating enzyme inhibitor pevonedistat is being evaluated in combination with azacitidine versus single-agent azacitidine ......

Population Pharmacokinetic Analysis of the BTK Inhibitor Zanubrutinib in Healthy Volunteers and Patients With B-Cell Malignancies

期刊: CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2021; 14 (2)

Zanubrutinib is a potent, second-generation Bruton's tyrosine kinase inhibitor that is currently being investigated in patients with B-cell malignanci......

Evolving drug regulatory landscape in China: A clinical pharmacology perspective

期刊: CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2021; 14 (4)

In order to encourage innovative medicine to address Chinese unmet medical needs, China has changed its drug regulatory landscape to speed up access t......

Sarcopenia in Patients With Normal Body Mass Index Is an Independent Predictor for Postoperative Complication and Long-Term Survival in Gastric Cancer

期刊: CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2021; 14 (3)

Malnutrition in patients with gastric cancer (GC) with normal body mass index (BMI) is often ignored. This study aimed to explore the role of sarcopen......

Safety, tolerability, pharmacokinetics, and pharmacodynamics of a TLR7 agonist prodrug RO6870868 in healthy volunteers

期刊: CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2021; 14 (4)

RO6870868 is an oral prodrug of the toll-like receptor 7 (TLR7) specific agonist, RO6871765. TLR7 agonists augment host immune activity and are in dev......

Outcomes of concurrent versus sequential icotinib therapy and chemotherapy in advanced non-small cell lung cancer with sensitive EGFR mutations

期刊: CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2021; 14 (3)

To explore a better treatment strategy for patients with advanced non-small cell lung cancer harboring sensitive epidermal growth factor receptor muta......

Good Manufacturing Practice-Grade of Megakaryocytes Produced by a Novel Ex Vivo Culturing Platform

期刊: CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2020; 13 (6)

Ex vivo(EV)-derived megakaryocytes (MKs) have shown great promise as a substitute for platelets in transfusion medicine to alleviate a severe shortage......

Bromhexine Hydrochloride Tablets for the Treatment of Moderate COVID-19: An Open-Label Randomized Controlled Pilot Study

期刊: CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2020; 13 (6)

This open-label randomized controlled pilot study aimed to test the study feasibility of bromhexine hydrochloride (BRH) tablets for the treatment of m......

The Potential of Low Molecular Weight Heparin to Mitigate Cytokine Storm in Severe COVID-19 Patients: A Retrospective Cohort Study

期刊: CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2020; 13 (6)

On March 11, 2020, the World Health Organization declared its assessment of coronavirus disease 2019 (COVID-19) as a global pandemic. However, specifi......

Risk of Metformin in Patients With Type 2 Diabetes With COVID-19: A Preliminary Retrospective Report

期刊: CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2020; 13 (6)

The current outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread across the world. No specific antiviral ......

Development and Validation of a Risk Prediction Model of Vancomycin-Associated Nephrotoxicity in Elderly Patients: A Pilot Study

期刊: CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2020; 13 (3)

This exploratory study aimed to develop a risk prediction model of vancomycin-associated nephrotoxicity (VANT) in elderly patients. Clinical informati......

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