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PTEN mediates serum deprivation-induced cytotoxicity in H9c2 cells via the PI3K/AKT signaling pathway

期刊: TOXICOLOGY IN VITRO, 2021; 73 ()

The pathogenesis of acute myocardial infarction (AMI) is associated with cardiomyocyte necrosis and apoptosis. Numerous studies have determined the re......

p53-mediated ferroptosis is required for 1-methyl-4-phenylpyridinium-in-duced senescence of PC12 cells

期刊: TOXICOLOGY IN VITRO, 2021; 73 ()

Parkinson?s disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra and striatum. Aging is the most important risk f......

USP18 mitigates lipopolysaccharide-induced oxidative stress and inflammation in human pulmonary microvascular endothelial cells through the TLR4/NF-kappa B/ROS signaling

期刊: TOXICOLOGY IN VITRO, 2021; 75 ()

As a type I interferon response gene, ubiquitin-specific protease 18 (USP18) has been shown to be widely involved in oxidative stress and immune regul......

Calycosin induces mitochondrial-dependent apoptosis and cell cycle arrest, and inhibits cell migration through a ROS-mediated signaling pathway in HepG2 hepatocellular carcinoma cells

期刊: TOXICOLOGY IN VITRO, 2021; 70 ()

Calycosin is one of the main ingredients extracted from the Chinese medical herb, Radix astragali (RA). It has been shown to inhibit cell proliferatio......

PARP-1 via regulation of p53 and p16, is involved in the hydroquinone-induced malignant transformation of TK6 cells by decelerating the cell cycle

期刊: TOXICOLOGY IN VITRO, 2021; 74 ()

Poly(ADP-ribose)polymerase-1 (PARP-1) plays a crucial role in DNA damage repair and could be viewed as both a tumor promoter and tumor-suppressor gene......

Increased effects of 2,5-dimethylcelecoxib on sensitivity of hepatocellular carcinoma cells to sorafenib via CYP3A5 expression and activation of AMPK

期刊: TOXICOLOGY IN VITRO, 2021; 76 ()

As the occurrence and development of HCC are often accompanied by inflammation, the combination of sor-afenib with other therapeutic drugs, especially......

In vitro toxicological evaluation of a tobacco heating product THP COO and 3R4F research reference cigarette on human lung cancer cells

期刊: TOXICOLOGY IN VITRO, 2021; 74 ()

Cigarette smoking increases health risks, such as respiratory diseases and heart diseases. Despite the decline in smoking rates in some countries, mil......

Application of in vitro methods to evaluate the safety of baby care products

期刊: TOXICOLOGY IN VITRO, 2021; 75 ()

Draize rabbit eye irritation and skin irritation tests are widely used in the chemical industry as traditional methods to evaluate the safety of cosme......

Silica nanoparticle induces pulmonary fibroblast transdifferentiation via macrophage route: Potential mechanism revealed by proteomic analysis

期刊: TOXICOLOGY IN VITRO, 2021; 76 ()

Recently, more and more attention has been focused on silica nanoparticles (SiNPs) as they are increasingly used in various fields. Yet, their biologi......

Effect of silibinin on ethanol- or acetaldehyde-induced damge of mouse primary hepatocytes in vitro

期刊: TOXICOLOGY IN VITRO, 2021; 70 ()

Silibinin, one of the flavonoids isolated from milk thistle seeds of Silybum marianum, has hepatoprotective properties against toxins in clinical. How......

Integration of transcriptomic, proteomic and metabolomic data to reveal the biological mechanisms of AAI injury in renal epithelial cells

期刊: TOXICOLOGY IN VITRO, 2021; 70 ()

Overexposure to aristolochic acid I (AAI) can induce aristolochic acid nephropathy (AAN). However, the comprehensive mechanisms of AAI-induced nephrot......

Cellular evaluation of the metal-organic framework PCN-224 associated with inflammation and autophagy

期刊: TOXICOLOGY IN VITRO, 2021; 70 ()

Metal-organic frameworks (MOFs) are innovative porous structures consisting of metal ions and organic ligands, which have been verified for extraordin......

Toluene diisocyanate-induced inflammation and airway remodeling involves autophagy in human bronchial epithelial cells

期刊: TOXICOLOGY IN VITRO, 2021; 70 ()

Toluene-diisocyanate (TDI) is one of the main causes of occupational asthma. To study the role of autophagy in TDI-induced airway inflammation and air......

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