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Effects of vitamin K-2 combined with methotrexate against mitogen-activated peripheral blood mononuclear cells of healthy subjects and rheumatoid arthritis patients

期刊: FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2021; 35 (5)

Background Methotrexate (MTX) is used as anchor drug for patients with early and established rheumatoid arthritis (RA). Vitamin K-2 administration was......

Function of intestinal barrier protected by regulating the miR-199a-3p in ulcerative colitis: Modulation of IL-23/IL-17A axis

期刊: FUNDAMENTAL & CLINICAL PHARMACOLOGY, ; ()

Ulcerative colitis is a chronic inflammatory bowel disorder, which is having higher mortality rate. The present report evaluates the protective effect......

Exploring the beneficial role of ROCK inhibitors in sepsis-induced cerebral and cognitive injury in rats

期刊: FUNDAMENTAL & CLINICAL PHARMACOLOGY, ; ()

Sepsis-induced cerebral injury is a systemic inflammatory response associated with high mortality rate and cognitive impairment. Rho/ROCK pathway acti......

Na+, K+-ATPase participates in the protective mechanism of rat cerebral ischemia-reperfusion through the interaction with glutamate transporter-1

期刊: FUNDAMENTAL & CLINICAL PHARMACOLOGY, ; ()

Glutamate excitotoxicity in cerebral ischemia/reperfusion is an important cause of neurological damage. The aim of this study was to investigate the m......

Mechanisms underlying the vasorelaxant effect of hydrogen sulfide on human saphenous vein

期刊: FUNDAMENTAL & CLINICAL PHARMACOLOGY, ; ()

Hydrogen sulfide (H2S) represents the third and the youngest member of the gaseous transmitters family. The dominant effect of H2S on isolated vessels......

Fentanyl inhibits acute myeloid leukemia differentiated cells and committed progenitors via opioid receptor-independent suppression of Ras and STAT5 pathways

期刊: FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2021; 35 (1)

Fentanyl is a common sedative/analgesic used for intrathecal chemotherapy injection in children with acute leukemia. Given the contradictory findings ......

Omentin-1 attenuates adipose tissue inflammation via restoration of TXNIP/NLRP3 signaling in high-fat diet-induced obese mice

期刊: FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2020; 34 (6)

Omentin-1 is an adipokine expressed by the adipose tissue and is reduced in obesity. This study was designed to calculate the protective efficiency an......

Mineralocorticoid receptor antagonist-mediated cognitive improvement in a mouse model of Alzheimer's type: possible involvement of BDNF-H2S-Nrf2 signaling

期刊: FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2020; 34 (6)

The present study explored the role and mechanisms of mineralocorticoid receptor antagonists in beta-amyloid (A beta)-induced cognitive impairment. A ......

Acetyl-11-keto-beta-boswellic acid triggers premature senescence via induction of DNA damage accompanied by impairment of DNA repair genes in hepatocellular carcinoma cells in vitro and in vivo

期刊: FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2020; 34 (1)

Cellular senescence, a state of irreversible growth arrest, occurs in all somatic cells and causes the cells to exhaust replicative capacity. Recently......

Simvastatin enhances chemotherapy in cervical cancer via inhibition of multiple prenylation-dependent GTPases-regulated pathways

期刊: FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2020; 34 (1)

Aberrant activation of GTPases is common in cervical cancer, and their proper biological functions largely depend on a post-translational modification......

GPER-mediated, oestrogen-dependent visceral hypersensitivity in stressed rats is associated with mast cell tryptase and histamine expression

期刊: FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2020; 34 (4)

Visceral hypersensitivity (VH) is common in irritable bowel syndrome (IBS), and female patients are more likely to seek healthcare services for IBS-re......

Endogenous hydrogen sulfide alleviates methotrexate-induced cognitive impairment by attenuating endoplasmic reticulum stress-induced apoptosis via CHOP and caspase-12

期刊: FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2020; 34 (5)

The aim of this study was to estimate whether methotrexate (MTX) promotes cognitive impairment via increased ER stress and disrupted H2S signaling in ......

Activation of RAW264.7 macrophage by Exopolysaccharide from Aphanothece halaphytica (EPSAH) and the underlying mechanisms

期刊: FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2020; 34 (5)

Exopolysaccharide fromAphanothece halophytica(EPSAH), a potent antitumor agent and immunological adjuvant, was investigated for the activation effect ......

Annexin A13 predicts poor prognosis for lung adenocarcinoma patients and accelerates the proliferation and migration of lung adenocarcinoma cells by modulating epithelial-mesenchymal transition

期刊: FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2020; 34 (6)

This study aimed to investigate the role of ANXA13 in lung adenocarcinoma (LUAD) growth, migration, and the underlying mechanisms. Firstly, in the TCG......

Ketamine inhibits LPS-mediated BV2 microglial inflammation via NMDA receptor blockage

期刊: FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2020; 34 (2)

Microglial inflammation leads to the upregulation of proinflammatory cytokine and proinflammatory enzyme expression, resulting in inflammation-induced......

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