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Subcellular localization of the mouse PRAMEL1 and PRAMEX1 reveals multifaceted roles in the nucleus and cytoplasm of germ cells during spermatogenesis

期刊: CELL AND BIOSCIENCE, 2021; 11 (1)

Background Preferentially expressed antigen in melanoma (PRAME) is a cancer/testis antigen (CTA) that is predominantly expressed in normal gametogenic......

Bone marrow mesenchymal stem cells promote prostate cancer cell stemness via cell-cell contact to activate the Jagged1/Notch1 pathway

期刊: CELL AND BIOSCIENCE, 2021; 11 (1)

BackgroundMesenchymal stem cells (MSCs) play a crucial role in cancer development and tumor resistance to therapy in prostate cancer, but the influenc......

Long noncoding RNA SNHG1 promotes TERT expression by sponging miR-18b-5p in breast cancer

期刊: CELL AND BIOSCIENCE, 2021; 11 (1)

Background Long noncoding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) plays a positive role in the progression of human malignant tumors. How......

ADP/ATP translocase 1 protects against an alpha-synuclein-associated neuronal cell damage in Parkinson's disease model

期刊: CELL AND BIOSCIENCE, 2021; 11 (1)

Background: ADP/ATP translocase 1 (ANT1) is involved in the exchange of cytosolic ADP and mitochondrial ATP, and its defection plays an important role......

Persistent deficiency of mucosa-associated invariant T (MAIT) cells during alcohol-related liver disease

期刊: CELL AND BIOSCIENCE, 2021; 11 (1)

Background Alcohol-related liver disease (ALD) is a major cause of chronic liver diseases. Inflammatory response is a basic pathological feature of AL......

Galectin-3: a key player in microglia-mediated neuroinflammation and Alzheimer's disease

期刊: CELL AND BIOSCIENCE, 2021; 11 (1)

Alzheimer's disease (AD) is the most common cause of dementia and is characterized by the deposition of extracellular aggregates of amyloid-beta (A be......

Lipidomics profiling of goose granulosa cell model of stearoyl-CoA desaturase function identifies a pattern of lipid droplets associated with follicle development

期刊: CELL AND BIOSCIENCE, 2021; 11 (1)

Background Despite their important functions and nearly ubiquitous presence in cells, an understanding of the biology of intracellular lipid droplets ......

YTHDF2 alleviates cardiac hypertrophy via regulating Myh7 mRNA decoy

期刊: CELL AND BIOSCIENCE, 2021; 11 (1)

BackgroundPathological cardiac hypertrophy is a major contributor of heart failure (HF), which seriously threatens human's health world widely. Deregu......

Modaline sulfate promotes Oct4 expression and maintains self-renewal and pluripotency of stem cells through JAK/STAT3 and Wnt signaling pathways

期刊: CELL AND BIOSCIENCE, 2021; 11 (1)

Background Stem cells have been extensively explored for a variety of regenerative medical applications and they play an important role in clinical tr......

RRM2 silencing suppresses malignant phenotype and enhances radiosensitivity via activating cGAS/STING signaling pathway in lung adenocarcinoma

期刊: CELL AND BIOSCIENCE, 2021; 11 (1)

Background As one of the most common malignancy, lung adenocarcinoma (LUAD) is characterized by low 5-year survival rate. This research aimed to inves......

CD44 fucosylation on bone marrow-derived mesenchymal stem cells enhances homing and promotes enteric nervous system remodeling in diabetic mice

期刊: CELL AND BIOSCIENCE, 2021; 11 (1)

BackgroundDiabetes can cause extensive enteric nervous system (ENS) injuries and gastrointestinal motility disorder. In developing possible treatments......

Synonymous point mutation of gtfB gene caused by therapeutic X-rays exposure reduced the biofilm formation and cariogenic abilities of Streptococcus mutans

期刊: CELL AND BIOSCIENCE, 2021; 11 (1)

BackgroundThe shift of oral microbiota is a critical factor of radiation caries in head and neck cancer patients after the radiotherapy. However, the ......

Electric signals counterbalanced posterior vs anterior PTEN signaling in directed migration of Dictyostelium

期刊: CELL AND BIOSCIENCE, 2021; 11 (1)

Background Cells show directed migration response to electric signals, namely electrotaxis or galvanotaxis. PI3K and PTEN jointly play counterbalancin......

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