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Insulin-Mimic Components in Acer truncatum Leaves: Bio-Guided Isolation, Annual Variance Profiling and Regulating Pathway Investigated by Omics

期刊: PHARMACEUTICALS, 2021; 14 (7)

Insulin mimic can promote transporting glucose to muscle tissue and accelerate glucose consumption. It is commonly occurring in many functional foods ......

Screening and Selection of a New Medium for Diosgenin Production via Microbial Biocatalysis of Fusarium sp.

期刊: PHARMACEUTICALS, 2021; 14 (5)

Steroidal saponins are widely used as starting precursors and medical intermediates for the semi-/total-synthesis of hundreds of steroidal drugs. One ......

MicroRNA-100 Mediates Hydrogen Peroxide-Induced Apoptosis of Human Retinal Pigment Epithelium ARPE-19 Cells

期刊: PHARMACEUTICALS, 2021; 14 (4)

This study investigated the regulatory role of microRNA 100 (miR-100) in hydrogen peroxide (H2O2)-induced apoptosis of human retinal pigment epithelia......

Up-Regulated Vitamin D Receptor by Pelargonium sidoides Extract EPs (R) 7630 Contributes to Rhinovirus Defense in Bronchial Epithelial Cells

期刊: PHARMACEUTICALS, 2021; 14 (2)

EPs (R) 7630, extracted from Pelargonium sidoides, reduces the severity of viral upper respiratory tract infections. Vitamin D also improves anti-vira......

Identification of Anti-Inflammatory and Anti-Proliferative Neolignanamides from Warburgia ugandensis Employing Multi-Target Affinity Ultrafiltration and LC-MS

期刊: PHARMACEUTICALS, 2021; 14 (4)

Previous reports have illustrated that the incidence and mortality of cancer are increasing year by year worldwide. In addition, the occurrence, devel......

Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer's Disease

期刊: PHARMACEUTICALS, 2021; 14 (6)

KED and EDR peptides prevent dendritic spines loss in amyloid synaptotoxicity in in vitro model of Alzheimer's disease (AD). The objective of this pap......

Zebrafish Model in Ophthalmology to Study Disease Mechanism and Drug Discovery

期刊: PHARMACEUTICALS, 2021; 14 (8)

Visual impairment and blindness are common and seriously affect people's work and quality of life in the world. Therefore, the effective therapies for......

Human Pluripotent Stem-Cell-Derived Models as a Missing Link in Drug Discovery and Development

期刊: PHARMACEUTICALS, 2021; 14 (6)

Human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and human-induced pluripotent stem cells (hiPSCs), have the potenti......

Thyroid Hormone Effect on the Differentiation of Human Induced Pluripotent Stem Cells into Hepatocyte-Like Cells

期刊: PHARMACEUTICALS, 2021; 14 (6)

Human induced pluripotent stem cells (hiPSCs) hold great potential as an unlimited source for obtaining hepatocyte-like cells (HLCs) for drug research......

COVID-19 Vaccines: A Review of the Safety and Efficacy of Current Clinical Trials

期刊: PHARMACEUTICALS, 2021; 14 (5)

Various strategies have been designed to contain the COVID-19 pandemic. Among them, vaccine development is high on the agenda in spite of the unknown ......

Current Therapies in Clinical Trials of Parkinson's Disease: A 2021 Update

期刊: PHARMACEUTICALS, 2021; 14 (8)

Parkinson's disease (PD) is a progressive neurodegenerative disorder that currently has no cure, but treatments are available to improve PD symptoms a......

Drug-Loaded, Polyurethane Coated Nitinol Stents for the Controlled Release of Docetaxel for the Treatment of Oesophageal Cancer

期刊: PHARMACEUTICALS, 2021; 14 (4)

For several decades, self-expanding metal stents (SEMSs) have shown significant clinical success in the palliation of obstructive metastatic oesophage......

Preparation and Bioevaluation of Novel Tc-99m-Labeled Complexes with a 2-Nitroimidazole HYNIC Derivative for Imaging Tumor Hypoxia

期刊: PHARMACEUTICALS, 2021; 14 (2)

To develop novel Tc-99m-labeled single-photon emission computed tomography (SPECT) radiotracers for imaging hypoxia, a novel HYNICNM ligand (6-hydrazi......

Kinsenoside Alleviates 17 alpha-Ethinylestradiol-Induced Cholestatic Liver Injury in Rats by Inhibiting Inflammatory Responses and Regulating FXR-Mediated Bile Acid Homeostasis

期刊: PHARMACEUTICALS, 2021; 14 (5)

Cholestasis is an important predisposing factor of liver diseases, such as hepatocyte necrosis, liver fibrosis and primary biliary cirrhosis. In this ......

Effective Activation of BKCa Channels by QO-40 (5-(Chloromethyl)-3-(Naphthalen-1-yl)-2-(Trifluoromethyl)Pyrazolo [1,5-a]pyrimidin-7(4H)-one), Known to Be an Opener of KCNQ2/Q3 Channels

期刊: PHARMACEUTICALS, 2021; 14 (5)

QO-40 (5-(chloromethyl)-3-(naphthalene-1-yl)-2-(trifluoromethyl) pyrazolo[1,5-a]pyrimidin-7(4H)-one) is a novel and selective activator of KCNQ2/KCNQ3......

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