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Lipidomic analysis reveals disturbances in glycerophospholipid and sphingolipid metabolic pathways in benzene-exposed mice

期刊: TOXICOLOGY RESEARCH, 2021; 10 (4)

Benzene, a known occupational and environmental contaminant, has been recognized as the hematotoxin and human carcinogen. Lipids have a variety of imp......

Imidazolidinyl urea activates mast cells via MRGPRX2 to induce non-histaminergic allergy

期刊: TOXICOLOGY RESEARCH, 2021; 10 (3)

Imidazolidinyl urea (IU) is used as an antimicrobial preservative in cosmetic and pharmaceutical products. IU induces allergic contact dermatitis, how......

Pathogenic characteristics and treatment in 43 cases of acute colchicine poisoning

期刊: TOXICOLOGY RESEARCH, 2021; 10 (4)

Colchicine poisoning is complicated and has a high mortality rate. The aim of this study was to identify the pathogenic characteristics of colchicine ......

Propofol regulates miR-1-3p/IGF1 axis to inhibit the proliferation and accelerates apoptosis of colorectal cancer cells

期刊: TOXICOLOGY RESEARCH, 2021; 10 (4)

This study aimed to clarify the mechanism of propofol on proliferation and apoptosis of colorectal cancer (CRC) cell. SW620 and HCT15 cells were expos......

Protection of apigenin against acrylonitrile-induced sperm and testis injury in rats: involvement of activation of ASK1-JNK/p38 signaling pathway

期刊: TOXICOLOGY RESEARCH, 2021; 10 (2)

This study aims to clarify if apigenin (AP) could play a pivotal role in attenuating acrylonitrile (ACN)-induced sperm and testis injury by inhibiting......

Metabonomic approaches investigate diosbulbin B-induced pulmonary toxicity and elucidate its underling mechanism in male mice

期刊: TOXICOLOGY RESEARCH, 2021; 10 (2)

Air Potato Yam is widely used in the treatment of many conditions such as cancer, inflammation, and goiter. Diosbulbin B (DIOB) is the primary active ......

Lactate and blood ammonia on admission as biomarkers to predict the prognosis of patients with acute mushroom poisoning and liver failure: a retrospective study

期刊: TOXICOLOGY RESEARCH, 2021; 10 (4)

The diagnosis of liver damage induced by mushroom poisoning is still challenging. This study aims to screen the early biological indexes that could pr......

Promotion effects of DEHP on hepatocellular carcinoma models: up-regulation of PD-L1 by activating the JAK2/STAT3 pathway

期刊: TOXICOLOGY RESEARCH, 2021; 10 (3)

Di(2-ethylhexyl) phthalate (DEHP), as an endocrine disruptor, is often used as a plasticizer in various polyvinyl chloride plastic products and medica......

Sodium arsenite induces spatial learning and memory impairment associated with oxidative stress and activates the Nrf2/PPAR gamma pathway against oxidative injury in mice hippocampus

期刊: TOXICOLOGY RESEARCH, 2021; 10 (2)

Arsenic (As) is a ubiquitous environmental and industrial toxin with known correlates of oxidative stress and cognitive deficits in the brain. Nuclear......

Cdc25B is transcriptionally inhibited by IER5 through the NF-YB transcription factor in irradiation-treated HeLa cells

期刊: TOXICOLOGY RESEARCH, 2021; 10 (4)

Cervical cancer (CC) is a type of pelvic malignant tumor that severely threatens women's health. Current evidence suggests that IER5, as a potential r......

Protective effects of baicalin in a Caenorhabditis elegans model of Parkinson's disease

期刊: TOXICOLOGY RESEARCH, 2021; 10 (3)

Parkinson's disease (PD) is a common neurodegenerative disorder of the central nervous system. However, the pathogenetic mechanisms of PD are far from......

Hydroquinone exposure accumulates neutral lipid by the activation of CDP-DAG pathway in Saccharomyces cerevisiae

期刊: TOXICOLOGY RESEARCH, 2021; 10 (2)

Benzene metabolites (HQ and BQ) are toxic compounds and their presence in human cause alteration in cellular respiration and kidney damage. In the cur......

Aristolochic acid I induces impairment in spermatogonial stem cell in rodents

期刊: TOXICOLOGY RESEARCH, 2021; 10 (3)

Aristolochic acid I (AAI) is a natural bioactive substance found in plants from the Aristolochiaceae family and impairs spermatogenesis. However, whet......

Time-course miRNA alterations and SIRT1 inhibition triggered by adolescent lead exposure in mice

期刊: TOXICOLOGY RESEARCH, 2021; 10 (4)

Sirtuin 1 (SIRT1), the NAD-dependent histone deacetylase, has been extensively investigated due to its cognitive protective effect. Studies suggest mi......

Low molecular weight-PAHs induced inflammation in A549 cells by activating PI3K/AKT and NF-kappa B signaling pathways

期刊: TOXICOLOGY RESEARCH, 2021; 10 (1)

Our previous study has demonstrated that two low molecular weight-polycyclic aromatic hydrocarbons (LMW-PAHs), phenanthrene (Phe) and fluorene (Flu), ......

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