Journal of Hepatology 2021 vol. 74 j 638–648
Taken together, the oxidative stress response is attenuated in NEMODhepa/KEAP1Dhepa livers, reducing DNA damage and hepatocyte proliferation, and eventually leading to decreased fibrosis and HCC development.
Phosphorylation of Bad at Ser155, which is mediated by PKA (41), was alsoreduced
Dose responses of different promoters to tune the density of transcription factor YhaJ under ？induction levels
The baseline characteristics of the internal validation set were similar to those of the derivation set, except that the former patients were younger (66 vs. 68 years, p < 0.001), had a lower mean aspartate minotransferase (AST) (45 vs. 57 IU/L, p < 0.001), alanine transaminase (ALT) (34 vs. 41 IU/L, p = 0.003), NLR (2.8 vs. 3.5, p < 0.001).
Prognostic value of PKR and AMPK in NSCLC patientsWe next analyzed the effects of the combination of PKR and p-AMPK on the overall survival of 299 NSCLC patients (194 adenocarcinoma and 105 squamous cell carcinoma). We used PKR and p-AMPK levels to stratify patients into four groups: those with high expression of PKR and with p-AMPK expression; those with high PKR expression and without p-AMPK expression; those with low PKR expression and with p-AMPK expression; and those with low PKR expression and without p-AMPK expression. Among the four stratified groups, overall survival did not differ significantly for squamous cell carcinoma patients (P = 0.18;Figure 5A); however, adenocarcinoma patients did have significantly different overall survival (P < 0.0001,Figure 5B). Among 194 adenocarcinoma patients, 72 PKRHigh/p-AMPKPositivepatients had slightly worse overall survival than did 34 PKRHigh/p-AMPKNegativepatients (Figure 5Band5C). In addition, we observed that 50 PKRLow/p-AMPKPositivepatients had better overall survival than did 38 PKRLow/p-AMPKNegativepatients (Figure 5Band5D). Representative images of PKR and p-AMPK expression in the cytoplasm of NSCLC cells are shown inFigure 5E. We also determined the PKR-p-AMPK relationship using Fisher’s exact test and Spearman’s correlation coefficient. We have demonstrated that PKR is positively correlated with p-AMPK in patients’ samples (Spearman’s rho=0.12; P = 0.03). Univariate and multivariate Cox proportional hazards regression analysis revealed that pathologic stage and PKR/p-AMPK expression significantly affected overall survival (Data not shown). Our results suggest that p-AMPK may promote tumor growth in adenocarcinoma patients with high PKR expression and may suppress tumor growth in adenocarcinoma patients with low PKR expression.Figure 5: The prognostic significance assessed with Kaplan-Meier survival estimates and log-rank test.(A-E) Kaplan-Meier survival curves showing the differences in survival duration using PKR combined with phosphorylated (p-)AMPK in all stages of squamous cell carcinoma (SCC) (A) and adenocarcinoma (ADC) (B-D) lung cancer patients. The survival rate in ADC patients with PKRlow/p-AMPKnegativewas significantly lower than that in ADC patients with PKRlow/p-AMPKpositive, ADC patients with PKRhigh/p-AMPKpositive, and ADC patients with PKRhigh/p-AMPKnegative(B-D). Immunohistochemical staining examples for the expressions of PKR and p-AMPK in the cytoplasm of NSCLC cells (original magnification x400) (E).
Therefore, 66% of the time the nomogram correctly predicted the ordering of the OS outcome of two randomly selected patients.因此，在66%的时间里，诺模图正确地预测了两个随机选择的患者的OS结局的顺序。
Fig. 1 shows the nomogram to predict the probability of 1-year OS and median survival. Fig. 2A illustrates the discriminatory value of the nomogram when the patients were stratified into good (nomogram score less than 24, N Z 93, median OS 25.3 months), intermediate (nomogram score 24e47,N =151, median OS 15.2 months) and poor risk (nomogram score greater than 47, N = 87, median OS 7.4 months) prognostic groups (log-rank P < .001).Performance status had the greatest prognostic significance, contributing a maximum of 38 points out of 100. 其中占比最大的是When compared with the good-risk group, the poor-risk and the intermediate-risk groups were associated with a 4.60-fold increase (hazard ratio [HR] 4.60, 95% confidence interval [CI] 3.20e6.63) and 2.08-fold increase (HR 2.08, 95% CI 1.50e2.88) in the risk of death, respectively. A比B增加了几倍的风险 用来描述 HR的
Fifty-five percent (6/11) of patients in the TACE-only group and 57% (8/14) of patients in the TACE plus thymalfasin group were anti-HCV positive.
Exp Ther Med . 2020 Dec;20(6):189. doi: 10.3892/etm.2020.9319
In order to assess the QoL, several parameters were analyzed, both at younger and older ages, illustrated inTable II. The highest IDQOL scores were found in pruritus, child's disposition, and treatment problems. The lowest scores were related to sleep disturbance and the time needed to fall asleep. In older children, the QoL assessed by CDLQI, in both age groups, the highest scores were related to problems during school, holidays and pruritus. The lowest scores for these age groups were obtained on questions related to sleep and treatment. The significant difference between the 2 groups, respectively 5-9 and 10-16 years, was obtained concerning the swimming questions. At this question, the highest QoL deficiency was obtained in children aged 5-9 years. Other significant elements between the 2 groups would be questions about teasing, intimidation, sleep problems and hobbies. These questions had higher values in children aged 5-9 years compared with those in the group of 10-16 years.
Exp Ther Med . 2020 Dec;20(6):189. doi: 10.3892/etm.2020.9319
The study included 64 patients aged from 0 to 16 years. The evaluated parameters of the patients included in the study according to age are shown inTable I. The cases were divided into 3 different age groups: 0-4 years (with a mean age of 1.94 years), 5-9 years (with a mean age of 7.08 years) and 10-16 years (with a mean age of 13.12 years). In the 3 months to 4 years group the predominant gender was male, representing 60.9%, and the females were 39.1%. In the further two age groups, the ratio of female to male patients was 50/50%. The 3 age groups did not differ significantly according to gender. Analyzing the associations with other diseases, we found statistically significant differences, regarding the presence of the associated atopic diseases and the severity of AD. The association of concomitant allergic diseases was more common in children from groups 5-9 and 10-16 years, than in the youngest group. The severity score, estimated with the help of the SCORAD index, was higher in the age groups 5-9 and 10-16 years. The most widespread form, according to severity was the mild form (54.7%), followed by the moderate form (35.9%) and the severe form (9.4%). The severe form was found with predilection in patients over 5 years of age.
对不同时效温度处理后的试样进行室温力学性能检测，数据如图3a所示。
Fig. 3a shows the mechanical properties of the specimen treated at different aging temperatures.
