introduction中有关关键基因的介绍 introduction

PLoS Med. 2006 October; 3(10): e420.

Nuclear factor erythroid-2 related factor 2 (NRF2), a cap 'n' collar basic leucine zipper transcription factor, regulates a transcriptional program that maintains cellular redox homeostasis and protects cells from oxidative insult, including from chemotherapeutic agents [7–9]. NRF2 activates transcription of its target genes through binding specifically to the antioxidant response element (ARE) found in those gene promoters. The NRF2-regulated transcriptional program includes a broad spectrum of genes, including ones encoding antioxidants (e.g., γ-glutamyl cysteine synthetase modifier subunit [GCLm], γ-glutamyl cysteine synthetase catalytic subunit [GCLc], heme oxygenase-1, superoxide dismutase, glutathione reductase [GSR], glutathione peroxidase, thioredoxin, thioredoxin reductase, peroxiredoxins[PRDX], and cysteine/glutamate transporter [SLC7A11]) [7,8], xenobiotic metabolism enzymes (e.g., NADP[H] quinone oxidoreductase 1 [NQO1], GSTs, and UDP-glucuronosyltransferase) [7,8], and several ATP-dependent drug efflux pumps (e.g., MRP1 and MRP2) [10–12].

HOX cofactors expression and regulation in the human ovary title

Reproductive Biology and Endocrinology 2008, 6:49

HOX cofactors enhance HOX binding affinities and specificities and increase HOX's unique functional activities. The expression and the regulation of HOX cofactors in human ovaries are unknown.

转录因子在肿瘤中的作用背景 introduction

Reproductive Biology and Endocrinology 2008, 6:49

Transcription factors play important roles in oogenesis and folliculogenesis [1,2]. Numerous studies have emphasized the importance of ovarian-specific transcription factor genes during ovarian follicular development. However, non-ovarian-specific genes are also expressed during ovarian follicular development, and their potential functions in folliculogenesis, such as steroidogenesis, are not known [3-5]. 三句话的逻辑结构，一是转录因子的普遍作用，二是大部分研究局限于某一方面，三是还有哪一点是目前没有研究的。 如果下一段，肯定写本文的研究主要focus这一点，便顺理成章了。