笔记详情
标题
pAkt and p-mTOR expression were inhibited by metformin
内容
pAkt and p-mTOR expression were inhibited by metformin
Phosphorylated protein kinase B (pAkt) and phosphorylated mTOR (p-mTOR), are the 2 common downstream signaling molecules for action of CRD, AMPK and SIRT1 [21, 36, 39–41]. CRD mice had the lowest and HED and RD mice had the highest expression of pAkt (Figure 7A, 7B) and p-mTOR (Figure 7C, 7D) as reported previously [13]. Metformin treatment reduced both pAkt and p-mTOR expression in HED and RD groups in the peritoneal and adipose tissue, similar to CRD (Figure 7A–7D). The quantification of the staining intensity is represented as bar graphs. This demonstrates that metformin modulated common oncogenic factors with CR, even under HED conditions. 点击翻译
Phosphorylated protein kinase B (pAkt) and phosphorylated mTOR (p-mTOR), are the 2 common downstream signaling molecules for action of CRD, AMPK and SIRT1 [21, 36, 39–41]. CRD mice had the lowest and HED and RD mice had the highest expression of pAkt (Figure 7A, 7B) and p-mTOR (Figure 7C, 7D) as reported previously [13]. Metformin treatment reduced both pAkt and p-mTOR expression in HED and RD groups in the peritoneal and adipose tissue, similar to CRD (Figure 7A–7D). The quantification of the staining intensity is represented as bar graphs. This demonstrates that metformin modulated common oncogenic factors with CR, even under HED conditions. 点击翻译
来源
Zaid Al-Wahab. Oncotarget. 2015 Mar 12
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