Figure 5
Location of Kir2.1 mutations used in the study
A and B, crystal structure of C terminus of Kir2.1 channel (Pegan et al. 2005) was visualized using Swiss-PDB Viewer software. Two opposing subunits were removed for clarity and side chains for the mutants used in this study displayed. A represents a side view, and B shows a top view of the pore region. C, sequence alignment of Kir2 channels in the region around the residues critical for inward rectification. Arrowhead points to the highly conserved F254 residue and asterisk indicates the least conserved site in this region.
