笔记详情
标题
自噬与凋亡
内容
Autophagy also may have synergistic effect on apoptosis, hence affecting the development of colorectal carcinoma. Other authors have also reported that the expressions of autophagy-related gene LC3 and Beclin-1 increase in colorectal carcinoma and these expressions are in accordance with those of anti-apoptotic genes p53 and Bcl-2 [24]. Under conditions in which apoptosis was induced with 5-fluorouracil (5-FU) or cisplatin, the apoptosis increased when autophagy was inhibited by 3-MA [25,26]. Reagents which inhibit autophagy are even thought as a combination therapy with antitumor drugs to enhance the therapeutic effect [27]. In order to study the effect of starvation-induced autophagy mediated by ART1 in the progression of CT26 cells, we observed the apoptosis and growth ability of GFP-ART1 group in the absence or presence of 3-MA. Data from the present study show that inhibition of starvation-induced autophagy in ART1-GFP CT26 cells promotes apoptosis and inhibits proliferation. This suggests that autophagy, which is regulated by ART1, may contribute to the survival of cancer cells under starvation conditions.
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来源
Am J Cancer Res. 2015 Jan 15;5(2):498-513.
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