笔记详情
标题
Impact of EGFR mutational heterogeneity on response to EGFR-TKIs
内容
Impact of EGFR mutational heterogeneity on response to EGFR-TKIs
Among 85 cases, 26 patients received EGFR-TKIs as first-line or multi-line therapies. 9 patients exhibited a partial response (PR), 7 had stable disease (SD), and 10 experienced progressive disease (PD). According to ARMS results, the mean mutant content was 86.1% (247/287) in the PR group, 48.7% (110/226) in the SD group, and 6.0% (19/317) in the PD group, and with a significant difference (P = 0.001).
We divided 26 patients into three subgroups according to EGFR mutation heterogeneous status, which were “pure wild type EGFR”, “EGFR mutation with heterogeneity” and “pure mutated EGFR”. The PFS were 3.01 months (95% CI 0.51–5.52), 11.35 months (95%CI 6.37–15.21) and 16.21 months (95%CI 8.21–25.19) for the three groups, respectively (P = 0.001). 点击翻译
Among 85 cases, 26 patients received EGFR-TKIs as first-line or multi-line therapies. 9 patients exhibited a partial response (PR), 7 had stable disease (SD), and 10 experienced progressive disease (PD). According to ARMS results, the mean mutant content was 86.1% (247/287) in the PR group, 48.7% (110/226) in the SD group, and 6.0% (19/317) in the PD group, and with a significant difference (P = 0.001).
We divided 26 patients into three subgroups according to EGFR mutation heterogeneous status, which were “pure wild type EGFR”, “EGFR mutation with heterogeneity” and “pure mutated EGFR”. The PFS were 3.01 months (95% CI 0.51–5.52), 11.35 months (95%CI 6.37–15.21) and 16.21 months (95%CI 8.21–25.19) for the three groups, respectively (P = 0.001). 点击翻译
来源
PLoS One. 2013; 8(2): e54170.
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