Knockdown of CDK5 down-regulates PD-L1 via the ubiquitination-proteasome pathway and improves antitumor immunity in lung adenocarcinoma

Gao, L; Xia, LL; Ji, WX; Zhang, YS; Xia, WL; Lu, S

Lu, S (corresponding author), Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Dept Shanghai Lung Canc Ctr, 241 Huaihai West Rd, Shanghai 200030, Peoples R China.; Xia, WL (corresponding author), Shanghai Jiao Tong Univ, Sch Biomed Engn, State Key Lab Oncogenes & Related Genes, 1954 HuashanRoad, Shanghai 200030, Peoples R China.

TRANSLATIONAL ONCOLOGY, 2021; 14 (9):

Abstract

Although immunotherapy (anti-PD-1/PD-L1 antibodies) has been approved for clinical treatment of lung cancer, only a small proportion of patients respo......

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