The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency

Gatti, M; Imhof, R; Huang, QY; Baudis, M; Altmeyer, M

Altmeyer, M (corresponding author), Univ Zurich, Dept Mol Mech Dis, CH-8057 Zurich, Switzerland.

CELL REPORTS, 2020; 32 (5):

Abstract

PARP inhibitors (PARPi) cause synthetic lethality in BRCA-deficient tumors. Whether specific vulnerabilities to PARPi exist beyond BRCA mutations and ......

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