In vitro and in vivo characterization of SARS-CoV-2 resistance to ensitrelvir

Kiso, M; Yamayoshi, S; Iida, S; Furusawa, Y; Hirata, Y; Uraki, R; Imai, M; Suzuki, T; Kawaoka, Y

Yamayoshi, S; Kawaoka, Y (通讯作者)，Univ Tokyo, Inst Med Sci, Div Virol, Tokyo, Japan.;Yamayoshi, S (通讯作者)，Univ Tokyo, Inst Med Sci, Int Res Ctr Infect Dis, Tokyo, Japan.;Yamayoshi, S; Kawaoka, Y (通讯作者)，Natl Ctr Global Hlth & Med Res Inst, Res Ctr Global Viral Dis, Tokyo, Japan.;Kawaoka, Y (通讯作者)，Univ Tokyo Pandem Preparedness, Infect & Adv Res Ctr, Tokyo, Japan.;Kawaoka, Y (通讯作者)，Univ Wisconsin Madison, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA.

NATURE COMMUNICATIONS, 2023; 14 (1):

Abstract

Ensitrelvir is an oral antiviral agent that targets SARS-CoV-2 and is clinically useful against infection with omicron variants. The authors character......

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