VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2

Gao, YH; Wu, ZX; Xie, LQ; Li, CX; Mao, YQ; Duan, YT; Han, B; Han, SF; Yu, Y; Lu, HJ; Yang, PY; Xu, TR; Xia, JL; Chen, GQ; Wang, LS

Wang, LS (reprint author), Fudan Univ, Inst Fudan Minhang Acad Hlth Syst, Minhang Hosp, 170 Xinsong Rd, Shanghai 201199, Peoples R China.; Chen, GQ; Wang, LS (reprint author), Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp,Shanghai Univ Inst Chem Biol E, K

NATURE COMMUNICATIONS, 2017; 8 ( ):

Abstract

The von Hippel-Lindau (VHL) is deficient in B70% of clear-cell renal cell carcinomas (ccRCC), which contributes to the carcinogenesis and drug resista......

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