Design, synthesis, and biological evaluation of 1-methyl-1H-pyrazolo [4,3-b]pyridine derivatives as novel small-molecule inhibitors targeting the PD-1/PD-L1 interaction

Dai, XY; Wang, K; Chen, H; Huang, XP; Feng, ZQ

Feng, ZQ (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Act Subst Discovery & Druggabil E, Beijing 100050, Peoples R China.

BIOORGANIC CHEMISTRY, 2021; 114 ():

Abstract

Blockade of the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) signalling pathway is a promising tumour immunotherapeutic appro......

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