期刊： BIOORGANIC CHEMISTRY, 2021; 109 ()
t-Butyl 6-cyano-(3R,5R)-dihydroxyhexanoate ((3R,5R)-2) is an advanced chiral diol intermediate of the cholesterol-lowering drug atorvastatin. KmAKRM5 ......
期刊： BIOORGANIC CHEMISTRY, 2021; 110 ()
(2S, 3R)-4-methylsulfonylphenylserine [(2S, 3R)-MPS], a key chiral precursor for antibiotics florfenicol and thiamphenicol, could be asymmetrically sy......
期刊： BIOORGANIC CHEMISTRY, 2021; 111 ()
Immunotherapy via immune checkpoints blockade has aroused the attention of researchers worldwide. Inhibition of the programmed cell death-1 (PD-1)/pro......
期刊： BIOORGANIC CHEMISTRY, 2021; 111 ()
Ursolic acid (UA) is an accessible triterpenoid, widely applied in the design and synthesis of antitumor compounds. However, the mechanism of its anti......
期刊： BIOORGANIC CHEMISTRY, 2021; 114 ()
Dihydroartemisinin (DHA), a natural product isolated from the traditional Chinese herb Artemisia annua and one of the clinical frontline drugs against......
期刊： BIOORGANIC CHEMISTRY, 2021; 114 ()
Seven new diterpenoids, eupholenes A-G (1-7), including two presegetanes (1 and 2), four jatrophanes (3-6), and one paraliane (7), along with 19 known......
期刊： BIOORGANIC CHEMISTRY, 2021; 114 ()
For the Alzheimer's disease (AD) with complex pathogenesis, single target drugs represent one of the most effective therapeutic strategies in clinical......
期刊： BIOORGANIC CHEMISTRY, 2021; 109 ()
A series of 8-substituted sampangine derivatives have been designed, synthesized and tested for their ability to inhibit cholinesterase and penetrate ......
期刊： BIOORGANIC CHEMISTRY, 2021; 110 ()
Extensive evidence indicates that RNA G-quadruplexes have associated with some important cellular events. Investigation of RNA G-quadruplexes is thus ......
期刊： BIOORGANIC CHEMISTRY, 2021; 111 ()
Seven previously undescribed trichothecenes, named trichothecrotocins M-S (1-7), along with five known compounds, were isolated from rice cultures of ......
期刊： BIOORGANIC CHEMISTRY, 2021; 112 ()
Tumor cells mainly provide necessary energy and substances for rapid cell growth through aerobic perglycolysis rather than oxidative phosphorylation. ......
期刊： BIOORGANIC CHEMISTRY, 2021; 112 ()
Nine new pyrrole alkaloids, including two undescribed dimeric pyrrole 2-carbaldehyde alkaloids, lepipyrrolins A-B (1-2), seven pyrrole-alkaloid deriva......
期刊： BIOORGANIC CHEMISTRY, 2021; 114 ()
Blockade of the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) signalling pathway is a promising tumour immunotherapeutic appro......
期刊： BIOORGANIC CHEMISTRY, 2021; 109 ()
Aiming to discover potent anti-proliferative agents from the roots of Sophora flavescens, seven new prenylated flavanones were isolated, along with 16......
期刊： BIOORGANIC CHEMISTRY, 2021; 111 ()
A new series of pyrimidine-5-carbonitrile derivatives 8a-p carrying the 1,3-thiazole moiety has been designed and synthesized as novel anti-inflammato......
