Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives bearing 1,3-thiazole moiety as novel anti-inflammatory EGFR inhibitors with cardiac safety profile

Abdel-Aziz, SA; Taher, ES; Lan, P; Asaad, GF; Gomaa, HAM; El-Koussi, NA; Youssif, BGM

Abdel-Aziz, SA (corresponding author), Al Azhar Univ, Fac Pharm, Dept Pharmaceut Med Chem, Assiut 71524, Egypt.; Youssif, BGM (corresponding author), Assiut Univ, Fac Pharm, Pharmaceut Organ Chem Dept, Assiut 71526, Egypt.

BIOORGANIC CHEMISTRY, 2021; 111 ():

Abstract

A new series of pyrimidine-5-carbonitrile derivatives 8a-p carrying the 1,3-thiazole moiety has been designed and synthesized as novel anti-inflammato......

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