Mitochondrial double-stranded RNAs govern the stress response in chondrocytes to promote osteoarthritis development

Kim, S; Lee, K; Choi, YS; Ku, J; Kim, H; Kharbash, R; Yoon, J; Lee, YS; Kim, JH; Lee, YJ; Kim, Y

Kim, Y (通讯作者)，Korea Adv Inst Sci & Technol, Dept Chem & Biomol Engn, Daejeon 34141, South Korea.;Lee, YJ (通讯作者)，Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Div Rheumatol, Seongnam 13605, South Korea.;Lee, YJ (通讯作者)，Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul 03080, South Korea.;Kim, Y (通讯作者)，Korea Adv Inst Sci & Technol, KAIST Inst Hlth Sci & Technol KIHST, Daejeon 34141, South Korea.;Kim, Y (通讯作者)，Korea Adv Inst Sci & Technol, KAIST Inst BioCentury, Daejeon 34141, South Korea.;Kim

CELL REPORTS, 2022; 40 (6):

Abstract

Protein kinase R (PKR) is an immune response protein that becomes activated by double-stranded RNAs (dsRNAs). PKR overactivation is associated with de......

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