Structure-guided development of covalent TAK1 inhibitors

Tan, L; Gurbani, D; Weisberg, EL; Hunter, JC; Li, LB; Jones, DS; Ficarro, SB; Mowafy, S; Tam, CP; Rao, SM; Du, GY; Griffin, JD; Sorger, PK; Marto, JA; Westover, KD; Gray, NS

Gray, NS (reprint author), Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA.; Westover, KD (reprint author), Univ Texas Southwestern Med Ctr Dallas, Dept Biochem, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.

BIOORGANIC & MEDICINAL CHEMISTRY, 2017; 25 (3): 838

Abstract

TAK1 (transforming growth factor-beta-activated kinase 1) is an essential intracellular mediator of cytokineand growth factor signaling and a potentia......

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