Structure-guided microbial targeting of antistaphylococcal prodrugs

Miller, JJ; Shah, IT; Hatten, J; Barekatain, Y; Mueller, EA; Moustafa, AM; Edwards, RL; Dowd, CS; Planet, PJ; Muller, FL; Jez, JM; John, ARO

John, ARO (corresponding author), Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA.; John, ARO (corresponding author), Univ Penn, Dept Pediat, Perelman Sch Med, Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.; John, ARO (corresponding author), Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63108 USA.

ELIFE, 2021; 10 ():

Abstract

Carboxy ester prodrugs are widely employed to increase oral absorption and potency of phosphonate antibiotics. Prodrugging can mask problematic chemic......

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