PAR4-Mediated PI3K/Akt and RhoA/ROCK Signaling Pathways Are Essential for Thrombin-Induced Morphological Changes in MEG-01 Cells

Heo, Y; Jeon, H; Namkung, W

Namkung, W (通讯作者)，Yonsei Univ, Coll Pharm, Yonsei Inst Pharmaceut Sci, 85 Songdogwahak Ro, Incheon 21983, South Korea.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022; 23 (2):

Abstract

Thrombin stimulates platelets via a dual receptor system of protease-activated receptors (PARs): PAR1 and PAR4. PAR1 activation induces a rapid and tr......

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