Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase

Ribeiro, JM; Canales, J; Cabezas, A; Rodrigues, JR; Pinto, RM; Lopez-Villamizar, I; Costas, MJ; Cameselle, JC

Cameselle, JC (reprint author), Univ Extremadura, Fac Med, Dept Bioquim & Biol Mol & Genet, Grp Enzimol, Badajoz, Spain.

SCIENTIFIC REPORTS, 2018; 8 ():

Abstract

Cyclic ADP-ribose (cADPR) is a messenger for Ca2+ mobilization. Its turnover is believed to occur by glycohydrolysis to ADP-ribose. However, ADP-ribos......

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