Development of HER2-Specific Aptamer-Drug Conjugate for Breast Cancer Therapy

Jeong, HY; Kim, H; Lee, M; Hong, J; Lee, JH; Kim, J; Choi, MJ; Park, YS; Kim, SC

Kim, SC (corresponding author), Biois Co Ltd, Seoul 08390, South Korea.; Park, YS (corresponding author), Yonsei Univ, Dept Biomed Lab Sci, Wonju 26493, South Korea.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020; 21 (24):

Abstract

In this study, HER2 RNA aptamers were conjugated to mertansine (DM1) and the anti-cancer effectiveness of the conjugate was evaluated in HER2-overexpr......

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