Significance of Basal Membrane Permeability of Epithelial Cells in Predicting Intestinal Drug AbsorptionS

Yoshitomo, A; Asano, S; Hozuki, S; Tamemoto, Y; Shibata, Y; Hashimoto, N; Takahashi, K; Sasaki, Y; Ozawa, N; Kageyama, M; Iijima, T; Kazuki, Y; Sato, H; Hisaka, A

Hisaka, A (通讯作者)，Chiba Univ, Grad Sch Pharmaceut Sci, Clin Pharmacol & Pharmacometr, 1-8-1 Inohana,Chuo Ku, Chiba, Chiba 2608675, Japan.

DRUG METABOLISM AND DISPOSITION, 2023; 51 (3): 318

Abstract

Drug absorption from the gastrointestinal tract is often restricted by efflux transport by P-glycoprotein (P-gp) and metabolism by CYP3A4. Both locali......

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