Understanding the binding affinities between SFRP1 (CRD) , SFRP1 (Netrin) , Wnt (5B) and frizzled receptors 2, 3 and 7 using MD simulations

Sunkara, RR; Koulgi, S; Jani, V; Gadewal, N; Sonavane, U; Joshi, R; Waghmare, SK

Waghmare, SK (corresponding author), Tata Mem Hosp, Adv Ctr Treatment Res & Educ Canc ACTREC, Canc Res Inst, Stem Cell Biol Grp,Waghmare Lab, Navi Mumbai 410210, Maharashtra, India.; Sonavane, U (corresponding author), Ctr Dev Adv Comp, High Performance Comp Med & Bioinformat Grp, Pune, Maharashtra, India.; Gadewal, N (corresponding author), Tata Mem Hosp, Adv Ctr Treatment Res & Educ Canc ACTREC, Bioinformat Ctr, Canc Res Inst, Navi Mumbai, India.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, ; ():

Abstract

cWnt-signalling plays a crucial role in stem cell maintenance and tissue homeostasis. Secreted frizzled-related proteins(SFRP), Wnt inhibitors consist......

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