Toxicokinetic and bioavailability studies on retrorsine in mice, and ketoconazole-induced alteration in toxicokinetic properties

Li, J; Zhou, MY; Lai, XQ; Wang, Y; Zou, Y; Li, KN; Li, WW; Zheng, J

Li, WW; Zheng, J (通讯作者)，Minist Educ, Natl Engn Res Ctr Miaos Med & Engn, Res Ctr Dev & Applicat Ethn Med & TCM, Guiyang 550004, Guizhou, Peoples R China.;Li, WW; Zheng, J (通讯作者)，Guizhou Prov Key Lab Pharmaceut, Guiyang 550004, Guizhou, Peoples R China.;Zheng, J (通讯作者)，Shenyang Pharmaceut Univ, Wuya Coll Innovat, Shenyang 110016, Liaoning, Peoples R China.

BIOMEDICAL CHROMATOGRAPHY, 2022; 36 (2):

Abstract

Retrorsine (RTS) is a toxic retronecine-type pyrrolizidine alkaloid, which is widely distributed. The purpose of this study was to develop a high-perf......

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