NAD(+) improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1 alpha pathway-MedSci.cn

NAD(+) improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1 alpha pathway

Zhao, Y; Zhang, JW; Zheng, YL; Zhang, YX; Zhang, XJ; Wang, HM; Du, Y; Guan, J; Wang, XZ; Fu, JL

Wang, XZ; Fu, JL (corresponding author), Shanghai Jiao Tong Univ, Dept Neurol, Affiliated Peoples Hosp 6, 600 Yishan Rd, Shanghai 200233, Peoples R China.

JOURNAL OF NEUROINFLAMMATION, 2021; 18 (1):

Abstract

Background: Microglial-mediated neuroinflammation plays an important role in vascular dementia, and modulating neuroinflammation has emerged as a prom......

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