Selective activation of TWIK-related acid-sensitive K+ 3 subunit-containing channels is analgesic in rodent models

Liao, P; Qiu, YG; Mo, YQ; Fu, J; Song, ZP; Huang, L; Bai, SW; Wang, Y; Zhu, JJ; Tian, FY; Chen, Z; Pan, NF; Sun, EY; Yang, LH; Lan, X; Chen, YB; Huang, DP; Sun, PH; Zhao, LF; Yang, DH; Lu, WQ; Yang, TT; Xiao, JJ; Li, WG; Gao, ZB; Shen, B; Zhang, QS;

Jiang, RT (reprint author), Sichuan Univ, Natl Local Joint Engn Res Ctr Translat Med Anesth, Lab Anesthesia & Crit Care Med, West China Hosp,Dept Anesthesiol, Chengdu 610000, Sichuan, Peoples R China.; Yang, HY (reprint author), East China Normal Univ, Sc

SCIENCE TRANSLATIONAL MEDICINE, 2019; 11 (519):

Abstract

The paucity of selective agonists for TWIK-related acid-sensitive K+ 3 (TASK-3) channel, a member of two-pore domain K+ (K2P) channels, has contribute......

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