Targeting the TS dimer interface in bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa: Virtual screening identifies novel TS allosteric inhibitors

Ruiz, VG; Czyzyk, DJ; Kumar, VP; Jorgensen, WL; Anderson, KS

Anderson, KS (corresponding author), Yale Univ, Dept Pharmacol, Sch Med, 333 Cedar St, New Haven, CT 06520 USA.; Anderson, KS (corresponding author), Yale Univ, Dept Mol Biophys & Biochem, Sch Med, 333 Cedar St, New Haven, CT 06520 USA.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020; 30 (16):

Abstract

Effective therapies are lacking to treat gastrointestinal infections caused by the genus Cryptosporidium, which can be fatal in the immunocompromised.......

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