Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis

Duan, X; Perveen, R; Dandamudi, A; Adili, R; Johnson, J; Funk, K; Berryman, M; Davis, AK; Holinstat, M; Zheng, Y; Akbar, H

Akbar, H (corresponding author), Ohio Univ, Heritage Coll Osteopath Med, Dept Biomed Sci, Athens, OH 45701 USA.; Zheng, Y (corresponding author), Univ Cincinnati, Childrens Hosp, Med Ctr, Div Expt Hematol & Canc Biol, Cincinnati, OH 45229 USA.

SCIENTIFIC REPORTS, 2021; 11 (1):

Abstract

Gene targeting of Cdc42 GTPase has been shown to inhibit platelet activation. In this study, we investigated a hypothesis that inhibition of Cdc42 act......

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