Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS

Kanaan, NM; Sellnow, RC; Boye, SL; Coberly, B; Bennett, A; Agbandje-McKenna, M; Sortwell, CE; Hauswirth, WW; Boye, SE; Manfredsson, FP

Manfredsson, FP (reprint author), Michigan State Univ, Dept Translat Sci & Mol Med, 333 Bostwick Ave NE, Grand Rapids, MI 49503 USA.

MOLECULAR THERAPY-NUCLEIC ACIDS, 2017; 8 ( ): 184

Abstract

Adeno-associated virus (AAV) is the most common vector for clinical gene therapy of the CNS. This popularity originates from a high safety record and ......

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