TRIM37 controls cancer-specific vulnerability to PLK4 inhibition

Meitinger, F; Ohta, M; Lee, KY; Watanabe, S; Davis, RL; Anzola, JV; Kabeche, R; Jenkins, DA; Shiau, AK; Desai, A; Oegema, K

Meitinger, F; Desai, A; Oegema, K (corresponding author), Ludwig Inst Canc Res, La Jolla, CA 92093 USA.; Desai, A; Oegema, K (corresponding author), Univ Calif San Diego, Sect Cell & Dev Biol, Div Biol Sci, La Jolla, CA 92093 USA.; Desai, A; Oegema, K (corresponding author), Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA.

NATURE, 2020; 585 (7825): 440

Abstract

Acentrosomal assembly of the mitotic spindle upon inhibition of the PLK4 protein is shown to depend on the ubiquitin ligase TRIM37, with implications ......

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