Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer

Yeow, ZY; Lambrus, BG; Marlow, R; Zhan, KH; Durin, MA; Evans, LT; Scott, PM; Phan, T; Park, E; Ruiz, LA; Moralli, D; Knight, EG; Badder, LM; Novo, D; Haider, S; Green, CM; Tutt, ANJ; Lord, CJ; Chapman, JR; Holland, AJ

Chapman, JR (corresponding author), Univ Oxford, Weatherall Inst Mol Med, Mol Haematol Unit, Med Res Council MRC, Oxford, England.; Chapman, JR (corresponding author), Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.; Holland, AJ (corresponding author), Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Baltimore, MD 21205 USA.

NATURE, 2020; 585 (7825): 447

Abstract

TRIM37overexpression promotes centrosome dysfunction that drives genomic instability in breast cancer cell lines containing the recurrent 17q23 amplic......

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