CRISPR/Cas9 Edited RAS & MEK Mutant Cells Acquire BRAF and MEK Inhibitor Resistance with MEK1 Q56P Restoring Sensitivity to MEK/BRAF Inhibitor Combo and KRAS G13D Gaining Sensitivity to Immunotherapy

Turner, E; Chen, LP; Foulke, JG; Gu, ZZ; Tian, F

Gu, ZZ; Tian, F (通讯作者)，Amer Type Culture Collect ATCC, R&D, Gaithersburg, MD 20877 USA.

CANCERS, 2022; 14 (21):

Abstract

Simple Summary BRAF inhibitor drug resistance has been a long-time challenge in the treatment of melanoma with BRAF V600E mutation. This study employe......

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