Targeting HIF-activated collagen prolyl 4-hydroxylase expression disrupts collagen deposition and blocks primary and metastatic uveal melanoma growth

Kaluz, S; Zhang, Q; Kuranaga, Y; Yang, H; Osuka, S; Bhattacharya, D; Devi, NS; Mun, J; Wang, W; Zhang, RW; Goodman, MM; Grossniklaus, HE; Van Meir, EG

Van Meir, EG (corresponding author), Emory Univ, Dept Neurosurg, Atlanta, GA 30322 USA.; Grossniklaus, HE; Van Meir, EG (corresponding author), Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA.; Grossniklaus, HE (corresponding author), Emory Univ, Dept Ophthalmol, Atlanta, GA 30322 USA.; Van Meir, EG (corresponding author), Univ Alabama Birmingham, Dept Neurosurg, Birmingham, AL USA.; Van Meir, EG (corresponding author), Univ Alabama Birmingham, ONeal Comprehens Canc Ctr, Birmingham, AL USA.

ONCOGENE, 2021; 40 (33): 5182

Abstract

Uveal melanoma (UM) is the most prevalent primary intraocular malignancy in adults, and patients that develop metastases (similar to 50%) survive <......

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