Metabolism of 2 alpha-[2-(tetrazol-2-yDethyl]-1 alpha,25-dihydroxyvitamin D-3 by CYP24A1 and biological activity of its 24R-hydroxylated metabolite

Yasuda, K; Tohyama, E; Takano, M; Kittaka, A; Ohta, M; Ikushiro, S; Sakaki, T

Sakaki, T (reprint author), Toyama Prefectural Univ, Dept Pharmaceut Engn, Fac Engn, 5180 Kurokawa, Imizu, Toyama 9390398, Japan.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2018; 178 (): 333

Abstract

Our previous study revealed that the 2 alpha-substituted vitamin D analog 2 alpha-[2-(tetrazol-2-yl)ethyl]-1 alpha,25(OH)(2)D-3 (AH-1) exhibited a hig......

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