Increased MAPK1/3 Phosphorylation in Luminal Breast Cancer Related with PIK3CA Hotspot Mutations and Prognosis

Ramirez-Ardila, D; Timmermans, AM; Helmijr, JA; Martens, JWM; Berns, EMJJ; Jansen, MPHM

Jansen, MPHM (reprint author), Erasmus MC Canc Inst, Dept Med Oncol, Room Be402,POB 2040, NL-3000 CA Rotterdam, Netherlands.

TRANSLATIONAL ONCOLOGY, 2017; 10 (5): 854

Abstract

INTRODUCTION: While mutations in PIK3CA are most frequently (45%) detected in luminal breast cancer, downstream PI3K/AKT/mTOR pathway activation is pr......

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