Structural basis for inhibition of an archaeal CRISPR-Cas type I-D large subunit by an anti-CRISPR protein

Manav, MC; Van, LB; Lin, JZ; Fuglsang, A; Peng, X; Brodersen, DE

Brodersen, DE (corresponding author), Aarhus Univ, Dept Mol Biol & Genet, Gustav Wieds Vej 10c, DK-8000 Aarhus C, Denmark.; Peng, X (corresponding author), Univ Copenhagen, Dept Biol, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark.

NATURE COMMUNICATIONS, 2020; 11 (1):

Abstract

A hallmark of type I CRISPR-Cas systems is the presence of Cas3, which contains both the nuclease and helicase activities required for DNA cleavage du......

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