IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion

Lin, H; Yan, Y; Luo, YF; So, WY; Wei, XY; Zhang, XZ; Yang, XL; Zhang, J; Su, Y; Yang, XY; Zhang, BB; Zhang, KJ; Jiang, N; Chow, BKC; Han, WP; Wang, FC; Rao, F

Rao, F (corresponding author), Southern Univ Sci & Technol, Dept Biol, Sch Life Sci, Shenzhen, Guangdong, Peoples R China.

NATURE COMMUNICATIONS, 2021; 12 (1):

Abstract

COP1 and COP9 signalosome (CSN) are the substrate receptor and deneddylase of CRL4 E3 ligase, respectively. How they functionally interact remains unc......

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