Mavacamten stabilizes an autoinhibited state of two-headed cardiac myosin

Rohde, JA; Roopnarine, O; Thomas, DD; Muretta, JM

Thomas, DD; Muretta, JM (reprint author), Univ Minnesota, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018; 115 (32): E7486

Abstract

We used transient biochemical and structural kinetics to elucidate the molecular mechanism of mavacamten, an allosteric cardiac myosin inhibitor and a......

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