Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti-CTLA-4 antibody

Ha, D; Tanaka, A; Kibayashi, T; Tanemura, A; Sugiyama, D; Wing, JB; Lim, EL; Teng, KWW; Adeegbe, D; Newell, EW; Katayama, I; Nishikawa, H; Sakaguchi, S

Sakaguchi, S (reprint author), Osaka Univ, Immunol Frontier Res Ctr, Expet Immunol, Osaka 5650871, Japan.; Sakaguchi, S (reprint author), Kyoto Univ, Inst Frontier Life & Med Sci, Dept Regenerat Sci & Engn, Lab Expt Immunol, Kyoto 6068507, Japan.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019; 116 (2): 609

Abstract

Anti-CTLA-4 mAb is efficacious in enhancing tumor immunity in humans. CTLA-4 is expressed by conventional T cells upon activation and by naturally occ......

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