Photo-induced site-specific oxidative fragmentation of IgG1 mediated by iron(III)-containing histidine buffer: Mechanistic studies and excipient effects

Zhang, YL; Ballesteros, ME; Schöneich, C

Schöneich, C (通讯作者),Univ Kansas, Dept Pharmaceut Chem, 2093 Constant Ave, Lawrence, KS 66047 USA.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2023; 190 (): 121

Abstract

Fragmentation may compromise the clinical efficacy and safety profile of monoclonal antibodies (mAbs). We recently reported that Fe(III)-containing hi......

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