IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation

Hotter, D; Bosso, M; Jonsson, KL; Krapp, C; Sturzel, CM; Das, A; Littwitz-Salomon, E; Berkhout, B; Russ, A; Wittmann, S; Gramberg, T; Zheng, Y; Martins, LJ; Planelles, V; Jakobsen, MR; Hahn, BH; Dittmer, U; Sauter, D; Kirchhoff, F

Kirchhoff, F (reprint author), Univ Ulm, Med Ctr, Inst Mol Virol, D-89081 Ulm, Germany.

CELL HOST & MICROBE, 2019; 25 (6): 858

Abstract

The interferon gamma-inducible protein 16 (IFI16) is known as immune sensor of retroviral DNA intermediates. We show that IFI16 restricts HIV-1 indepe......

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