Mutant SF3B1 promotes AKT- and NF-kappa B driven mammary tumorigenesis

Liu, B; Liu, ZQ; Chen, SS; Ki, M; Erickson, C; Reis-Filho, JS; Durham, BH; Chang, Q; de Stanchina, E; Sun, YW; Rabadan, R; Abdel-Wahab, O; Chandarlapaty, S

Abdel-Wahab, O; Chandarlapaty, S (corresponding author), Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, 417 East 68th St, New York, NY 10065 USA.

JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (1):

Abstract

Mutations in the core RNA splicing factor SF381 are prevalent in leukemias and uveal melanoma, but hotspot SF3B1 mutations are also seen in epithelial......

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